We strive to identify innovative programs that involve
hitherto non-targeted proteins, in order to discover
drugs with novel mechanisms of action.
The drug discovery process starts with an idea
from our scientists. We scour the literature to see
what others have not yet discovered and to generate
ideas, and then translate them into a concept
that can lead to new treatments for patients.
Our work in the lab begins with the target. This
may be a particular protein which, when its
activity is modulated, can normalize a biological
process in the body – with a beneficial effect
for patients. To see whether we can affect the
protein’s activity, we first need to be able to
We produce, or “express”, the target in large
quantities and use assays to measure its natural
activity. The assay needs to be sensitive, accurate
and highly reliable. Plus, in order to perform
hundreds of thousands of measurements, it
needs to be automated, using robotic equipment.