We have a diversified and balanced clinical development pipeline that covers multiple therapeutic areas, including CNS, cardiovascular and immunological disorders, as well as orphan diseases.

Compound Mechanism of Action Target Indication Status More information
Daridorexant Dual orexin receptor antagonist Insomnia Phase 3 – recruitment complete Investor webcast
Aprocitentan*  Dual endothelin receptor antagonist Resistant hypertension management Phase 3 Investor webcast
Clazosentan Endothelin receptor antagonist Vasospasm associated with aneurysmal subarachnoid hemorrhage (aSAH) Phase 3 Investor webcast
Lucerastat Glucosylceramide synthase inhibitor Fabry disease Phase 3 Investor webcast
Cenerimod S1P1 receptor modulator Systemic lupus erythematosus Phase 2  
Selatogrel P2Y12 receptor antagonist Suspected acute myocardial infarction Phase 2 – complete  
ACT-774312 CRTH2 receptor antagonist Nasal polyposis Phase 2  
Sinbaglustat
(ACT-519276)		 GBA2/GCS inhibitor Rare CNS diseases Phase 1  
ACT-539313 Selective orexin 1 receptor antagonist Psychiatric disorders Phase 1  
ACT-709478** T-type calcium channel blocker Epilepsy Phase 1  
ACT-1004-1239 - Immunology / Cancer Immunotherapy Phase 1  
ACT-1014-6470 - Immunology Phase 1  


* In collaboration with Janssen Biotech to jointly develop and solely commercialize aprocitentan worldwide
** Idorsia has granted to Neurocrine Biosciences, Inc. an option to license ACT-709478, this option will expire 30 days after the IND application acceptance by the FDA, expected in mid-2020

Idorsia has the option to license vamorolone from ReveraGen Inc. and has granted to Santhera Holding Ltd. the option to sub-license vamorolone worldwide (except Japan and South-Korea) for all indications.

"We are all encouraged to talk, share, communicate and participate."

Clinical Research Associate, Global Operations